Penyakit Kolera adalah penyakit bawaan makanan dan air yang dilaporkan setiap tahun di Pengurusan Ujian Vibrio Cholera di Makmal Kesihatan Awam. Vibrio cholerae serogroup O1, the causative agent of the diarrheal disease cholera, is divided into two biotypes: classical and El Tor. Both biotypes produce the  Missing: adalah ‎| ‎Must include: ‎adalah. Vibrio cholerae is a Gram-negative, comma-shaped bacterium. The bacterium's natural habitat is brackish or saltwater. Some strains of V. cholerae cause the  Species‎: ‎V. cholerae.


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Although evidence has been presented demonstrating that the El Tor biotype has globally displaced the classical biotype 1942the emergence of Vibrio cholera adalah Tor variants has warranted the use of standard genotypic and phenotypic assays to determine the biotype background of new isolates.


Standard phenotypic assays, including polymyxin B resistance, hemolysis assays, phage sensitivities, and the Voges-Proskauer tests, are frequently employed in some combination 411 Genetic markers, such as the ctxB gene, have been used to distinguish the cholera toxin between classical and El Tor biotypes 113335 to classify isolates as El Tor variants.

The sequences of tcpA, vibrio cholera adalah codes for the pilin subunits of the TcpA apparatus, and rstR, the repressor found in the RS1 element, which codes for the regulatory region for phage replication, also have been used in determining the biotypes of new isolates 41139vibrio cholera adalah El Tor variants were first identified from sporadic strains of V.

We report the results of various genotypic and phenotypic assays used to determine the biotype background for each strain. However, more importantly, we report relative cholera toxin production levels expressed by all variants, the expression levels of the virulence factors TcpA and ToxT, and quantitative data for biofilm production and other phenotypic traits, and we compare these data to those for classical O, El Tor C, and El Tor N wild-type strains.

Cholera - Wikipedia

Finally, in agreement with the virulence factor production profiles, we demonstrate the virulence profile of the high producers of cholera toxin Bgd8 and MQas well vibrio cholera adalah some of the genetically different representative variant strains Bgd2, Bgd3, MQ04, and BAAusing the infant mouse cholera model.

The clinical profiles of the patients from Matlab Hospital in Bangladesh and representative data for the patients from Haiti are given in Table 1.

Colonization of the small intestine also requires the toxin coregulated pilus TCPa thin, vibrio cholera adalah, filamentous appendage on the surface of bacterial cells.

The disease is also particularly dangerous for pregnant women and their fetuses during late pregnancy, as it may cause premature labor and fetal death.

Classical Vibrio cholerae

The disease typically lasts 4—6 days. Genome[ edit ] V. The entire genome of the virulent strain V. The larger first chromosome contains the crucial genes for toxicity, regulation of toxicity, and important cellular functions, such as transcription and translation. And, unlike plasmids, chromosomes are not vibrio cholera adalah.

Inthe El Tor biotype a subset distinguished by physiologic characteristics of V cholerae, not previously implicated in widespread epidemics, emerged from the Celebes vibrio cholera adalah Sulawesicausing the seventh great cholera pandemic.

In the course of their migration, the El Tor biotype cholera vibrios virtually replaced V cholerae of the classic biotype that formerly was responsible for the annual cholera epidemics in India and East Pakistan now Bangladesh.

The pandemic that began in is now heavily seeded in Southeast Asia and in Africa.

Classical Vibrio cholerae | bacterium biotype |

It has also invaded Europe, North America, and Japan, where the outbreaks have been relatively restricted and self-limited because of more highly developed sanitation. Several new cases were reported in Texas in and sporadic cases have since been reported in Louisiana and other Gulf Coast areas.

This now endemic focus appears to be due to a clone which is unique from vibrio cholera adalah pandemic strain. Inthe pandemic strain hit Peru with massive force and has since spread through most of the Western Hemisphere, causing more than a million cases.

Fortunately, mortality has been less than 1 percent because of the effectiveness of oral rehydration therapy.

The vibrios surprised us again, inwith the emergence of O in India and Bangladesh. For a while it appeared that O would replace O1 both classical and El Tor but it has exhibited quiescent periods when O1 reemerges. Cholera appears to exhibit three major epidemiologic patterns: These patterns probably depend largely on environmental vibrio cholera adalah including sanitary and cultural aspectsthe prior immune status or antigenic experience of the population at risk, and the inherent properties of the vibrios themselves, such as their resistance to gastric acidity, ability to colonize, and toxigenicity.

In the heavily endemic region of the Indian subcontinent, cholera exhibits some periodicity; this may vary from year to year and seasonally, depending partly on vibrio cholera adalah amount of rain and degree of flooding.

Because humans are the only reservoirs, survival of the cholera vibrios during interepidemic periods probably depends on a relatively constant availability of low-level undiagnosed cases and transiently infected, asymptomatic individuals.

Vibrio cholera adalah carriers have been reported but are extremely rare. Her carrier state resolved spontaneously in ; no secondary cases had been associated with her well-marked strain.

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Although transmission occurs primarily through water contaminated with human feces, infection also may be spread within households and by contaminated foods.